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Mixed conductive and sensorineural hearing loss

DOID EFO MESH SNOMED PheWeb

H8_HL_MIX_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H90.6, H90.7, H90.8
Hospital discharge: ICD-9 3892
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H90.6, H90.7, H90.8
Cause of death: ICD-9 3892
Cause of death: ICD-8 $!$

3342

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3314

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Check minimum number of events None

3314

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Include endpoints None

3314

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H8_HL_MIX_NAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 3314 1762 1552
Unadjusted prevalence (%) 0.93 0.89 0.99
Mean age at first event (years) 59.92 57.65 62.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.92 [1.44, 2.55] 7.5e-6 400
15 years 0.01 1.32 [0.99, 1.77] 6.2e-2 225
5 years 0.00 1.82 [1.35, 2.46] 9.5e-5 101
1 year 0.00 2.64 [1.71, 4.07] 1.1e-5 27

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_MIX_NAS – Mixed conductive and sensorineural hearing loss
GWS hits:

Survival analyses between endpoints

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Plot

before Mixed conductive and sensorineural hearing loss
after Mixed conductive and sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed conductive and sensorineural hearing loss

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