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Sensorineural hearing loss

DOID EFO MESH SNOMED PheWeb

H8_HL_SEN_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H90.3, H90.4, H90.5
Hospital discharge: ICD-9 3891
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H90.3, H90.4, H90.5
Cause of death: ICD-9 3891
Cause of death: ICD-8 $!$

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

29197

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H8_HL_SEN_NAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 29197 13677 15520
Unadjusted prevalence (%) 8.21 6.89 9.86
Mean age at first event (years) 64.26 62.22 66.05

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.63 [1.43, 1.86] 7.0e-13 3939
15 years 0.01 1.02 [0.90, 1.15] 8.0e-1 1926
5 years 0.00 1.92 [1.73, 2.13] 9.3e-35 1311
1 year 0.00 2.64 [2.28, 3.06] 1.6e-38 348

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 21

Survival analyses between endpoints

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Plot

before Sensorineural hearing loss
after Sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sensorineural hearing loss

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