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Atrial fibrillation and flutter

DOID EFO MESH SNOMED PheWeb

I9_AF

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I48
Hospital discharge: ICD-9 4273
Hospital discharge: ICD-8 42792
Cause of death: ICD-10 I48
Cause of death: ICD-9 4273
Cause of death: ICD-8 42792
KELA reimbursements: KELA codes 207|351
KELA reimbursements: ICD-10 I48

42672

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

41788

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Check minimum number of events None

41788

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Include endpoints

41788

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I9_AF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Fibrillatio atriorum

Summary Statistics

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Key figures

All Female Male
Number of individuals 41788 15465 26323
Unadjusted prevalence (%) 11.75 7.79 16.73
Mean age at first event (years) 67.73 69.56 66.65

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.08 [2.78, 3.42] <1e-100 10445
15 years 0.01 1.65 [1.51, 1.81] 4.6e-27 3872
5 years 0.01 3.65 [3.39, 3.93] <1e-100 3530
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_AF – Atrial fibrillation and flutter
GWS hits: 97

Survival analyses between endpoints

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Plot

before Atrial fibrillation and flutter
after Atrial fibrillation and flutter

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Atrial fibrillation and flutter

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