Atrial fibrillation and flutter with reimbursement

I9_AF_REIMB

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

I9_AF

41788

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Filter registries

KELA reimbursements: KELA codes 207|351

20489

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Check pre-conditions, main-only, mode, ICD version None

20489

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Check minimum number of events None

20489

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Include endpoints None

20489

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I9_AF_REIMB

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 20489 8293 12196
Unadjusted prevalence (%) 5.76 4.18 7.75
Mean age at first event (years) 69.93 71.62 68.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.20 [1.85, 2.63] 1.3e-18 2879
15 years 0.01 1.05 [0.92, 1.19] 5.1e-1 955
5 years 0.00 2.43 [2.17, 2.72] 5.2e-52 987
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_AF_REIMB – Atrial fibrillation and flutter with reimbursement
GWS hits: 83

Survival analyses between endpoints

Plot

before Atrial fibrillation and flutter with reimbursement
after Atrial fibrillation and flutter with reimbursement

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Drugs most likely to be purchased after Atrial fibrillation and flutter with reimbursement