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Angina pectoris

DOID EFO MESH SNOMED PheWeb

I9_ANGINA

Prinzmetal's angina: a syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel walls rather than directly by atherosclerosis (buildup of fatty plaque and hardening of the arteries). For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I20
Hospital discharge: ICD-9 413|411[0-1]
Hospital discharge: ICD-8 413
Cause of death: ICD-10 I20
Cause of death: ICD-9 413|411[0-1]
Cause of death: ICD-8 413

31671

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

31661

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Check minimum number of events None

31661

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Include endpoints None

31661

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I9_ANGINA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I20-I25
Name in latin Angina pectoris

Summary Statistics

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Key figures

All Female Male
Number of individuals 31661 10468 21193
Unadjusted prevalence (%) 8.90 5.28 13.47
Mean age at first event (years) 63.09 64.05 62.62

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.09 [1.88, 2.32] 3.4e-43 9358
15 years 0.01 1.53 [1.40, 1.67] 3.9e-21 4631
5 years 0.00 2.20 [2.04, 2.38] 1.5e-88 2079
1 year 0.00 5.24 [4.68, 5.85] <1e-100 952

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_ANGINA – Angina pectoris
GWS hits: 52

Survival analyses between endpoints

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Plot

before Angina pectoris
after Angina pectoris

loading spinner Loading survival analyses plot