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Coronary atherosclerosis

DOID EFO MESH SNOMED PheWeb

I9_CORATHER

heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I24, I25, T82.2, Z95.1
Hospital discharge: ICD-9 414|9960A
Hospital discharge: ICD-8 414
Hospital discharge: excluded ICD-10 I25.3
Cause of death: ICD-10 I24, I25, T82.2, Z95.1
Cause of death: ICD-9 414|9960A
Cause of death: ICD-8 414
Cause of death: excluded ICD-10 I25.3

43769

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

43769

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Check minimum number of events None

43769

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Include endpoints None

43769

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I9_CORATHER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 43769 13087 30682
Unadjusted prevalence (%) 12.30 6.60 19.50
Mean age at first event (years) 67.42 68.30 67.05

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.30 [3.92, 4.70] <1e-100 14532
15 years 0.02 2.24 [2.05, 2.44] 4.6e-75 5116
5 years 0.01 3.89 [3.61, 4.19] <1e-100 3393
1 year 0.01 25.50 [23.14, 28.11] <1e-100 4881

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CORATHER – Coronary atherosclerosis
GWS hits: 81

Survival analyses between endpoints

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Plot

before Coronary atherosclerosis
after Coronary atherosclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Coronary atherosclerosis

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