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Peripheral artery disease

DOID EFO MESH SNOMED PheWeb

I9_PAD

peripheral arterial disease: A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E10.5, E10.5+I79.2, E11.5, E11.5+I79.2, E12.5, E13.5, E14.5, I70.2, I73.9
Hospital discharge: ICD-9 4402|4439
Hospital discharge: ICD-8 25006|4402|4439
Cause of death: ICD-10 E10.5, E10.5+I79.2, E11.5, E11.5+I79.2, E12.5, E13.5, E14.5, I70.2, I73.9
Cause of death: ICD-9 4402|4439
Cause of death: ICD-8 25006|4402|4439

13876

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

13876

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Check minimum number of events None

13876

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Include endpoints

14597

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I9_PAD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 14597 4373 10224
Unadjusted prevalence (%) 4.10 2.20 6.50
Mean age at first event (years) 66.90 66.80 66.94

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.12 [3.57, 4.75] 6.7e-84 5521
15 years 0.02 2.21 [1.95, 2.49] 8.9e-38 2289
5 years 0.01 4.26 [3.89, 4.66] <1e-100 1819
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_PAD – Peripheral artery disease
GWS hits:

Survival analyses between endpoints

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Plot

before Peripheral artery disease
after Peripheral artery disease

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Drugs most likely to be purchased after Peripheral artery disease

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