Rheumatic fever incl heart disease

I9_RHEUFEV

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 947 426 521
Unadjusted prevalence (%) 0.27 0.21 0.33
Mean age at first event (years) 50.18 47.14 52.67

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.37 [1.56, 3.60] 5.6e-5 328
15 years 0.01 1.36 [0.94, 1.96] 1.1e-1 128
5 years 0.00 2.25 [1.67, 3.04] 8.4e-8 71
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits:

Survival analyses between endpoints

Plot

before Rheumatic fever incl heart disease
after Rheumatic fever incl heart disease

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Drugs most likely to be purchased after Rheumatic fever incl heart disease