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Diseases of the circulatory system

PheWeb

IX_CIRCULATORY

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I00-I99
Hospital discharge: ICD-9 39|4[0-5]
Hospital discharge: ICD-8 39|4[0-5]
Cause of death: ICD-10 I00-I99
Cause of death: ICD-9 39|4[0-5]
Cause of death: ICD-8 39|4[0-5]

181061

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

181061

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Check minimum number of events None

181061

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Include endpoints None

181061

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IX_CIRCULATORY

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 181061 89751 91310
Unadjusted prevalence (%) 50.89 45.24 58.02
Mean age at first event (years) 53.95 51.27 56.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 5.70 [5.36, 6.05] <1e-100 30866
15 years 0.01 3.82 [3.56, 4.11] <1e-100 13274
5 years 0.01 5.60 [5.15, 6.09] <1e-100 6277
1 year 0.01 27.58 [23.42, 32.49] <1e-100 4970

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: IX_CIRCULATORY – Diseases of the circulatory system
GWS hits:

Survival analyses between endpoints

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Plot

before Diseases of the circulatory system
after Diseases of the circulatory system

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Drugs most likely to be purchased after Diseases of the circulatory system

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