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Hypersensitivity pneumonitis due to organic dust

DOID EFO MESH PheWeb

J10_HYPERSPNEUMONI

extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 J67
Hospital discharge: ICD-9 495
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 J67
Cause of death: ICD-9 495
Cause of death: ICD-8 $!$

419

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

408

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Check minimum number of events None

408

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Include endpoints None

408

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J10_HYPERSPNEUMONI

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J60-J70
Name in latin Pneumonitis/alveolitis hypersensitiva e pulvere organico

Summary Statistics

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Key figures

All Female Male
Number of individuals 408 212 196
Unadjusted prevalence (%) 0.11 0.11 0.12
Mean age at first event (years) 46.08 44.62 47.67

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.64 [1.30, 5.36] 7.2e-3 59
15 years 0.02 2.14 [1.20, 3.82] 9.5e-3 28
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: 1

Survival analyses between endpoints

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Plot

before Hypersensitivity pneumonitis due to organic dust
after Hypersensitivity pneumonitis due to organic dust

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypersensitivity pneumonitis due to organic dust

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