Pneumoconiosis due to dust containing silica

J10_SILICAPNEUMOC

silicosis: Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 J62
Hospital discharge: ICD-9 502
Hospital discharge: ICD-8 5150
Cause of death: ICD-10 J62
Cause of death: ICD-9 502
Cause of death: ICD-8 5150

276

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

90

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Check minimum number of events None

90

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Include endpoints None

90

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J10_SILICAPNEUMOC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J60-J70
Name in latin Silicosis

Summary Statistics

Key figures

All Female Male
Number of individuals 90 8 82
Unadjusted prevalence (%) 0.03 0.00 0.05
Mean age at first event (years) 61.57 53.23 62.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: J10_SILICAPNEUMOC – Pneumoconiosis due to dust containing silica
GWS hits:

Survival analyses between endpoints

Plot

before Pneumoconiosis due to dust containing silica
after Pneumoconiosis due to dust containing silica

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Drugs most likely to be purchased after Pneumoconiosis due to dust containing silica