Diaphragmatic hernia

K11_DIAHER

congenital diaphragmatic hernia: Congenital diaphragmatic hernia (CDH) is a posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K44
Hospital discharge: ICD-9 5513|5523|5533
Hospital discharge: ICD-8 5513
Cause of death: ICD-10 K44
Cause of death: ICD-9 5513|5523|5533
Cause of death: ICD-8 5513

10634

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

10634

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Check minimum number of events None

10634

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Include endpoints None

10634

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K11_DIAHER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K40-K46
Name in latin Hernia diaphragmatica

Summary Statistics

Key figures

All Female Male
Number of individuals 10634 6267 4367
Unadjusted prevalence (%) 2.99 3.16 2.77
Mean age at first event (years) 60.13 59.67 60.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.50 [2.03, 3.09] 1.5e-17 1210
15 years 0.01 1.42 [1.18, 1.69] 1.3e-4 523
5 years 0.00 2.83 [2.41, 3.33] 1.0e-36 394
1 year 0.00 5.64 [4.58, 6.93] 1.9e-60 155

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: K11_DIAHER – Diaphragmatic hernia
GWS hits: 7

Survival analyses between endpoints

Plot

before Diaphragmatic hernia
after Diaphragmatic hernia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diaphragmatic hernia