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Diaphragmatic hernia

DOID EFO MESH PheWeb

K11_DIAHER

congenital diaphragmatic hernia: Congenital diaphragmatic hernia (CDH) is a posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K44
Hospital discharge: ICD-9 5513|5523|5533
Hospital discharge: ICD-8 5513
Cause of death: ICD-10 K44
Cause of death: ICD-9 5513|5523|5533
Cause of death: ICD-8 5513

10634

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

10634

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Check minimum number of events None

10634

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Include endpoints None

10634

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K11_DIAHER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K40-K46
Name in latin Hernia diaphragmatica

Summary Statistics

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Key figures

All Female Male
Number of individuals 10634 6267 4367
Unadjusted prevalence (%) 2.99 3.16 2.77
Mean age at first event (years) 60.13 59.67 60.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.50 [2.03, 3.09] 1.5e-17 1210
15 years 0.01 1.42 [1.18, 1.69] 1.3e-4 523
5 years 0.00 2.83 [2.41, 3.33] 1.0e-36 394
1 year 0.00 5.64 [4.58, 6.93] 1.9e-60 155

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_DIAHER – Diaphragmatic hernia
GWS hits: 7

Survival analyses between endpoints

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Plot

before Diaphragmatic hernia
after Diaphragmatic hernia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diaphragmatic hernia

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