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Irritable bowel syndrome

DOID EFO MESH SNOMED PheWeb

K11_IBS

irritable bowel syndrome: Gastrointestinal symptoms characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K58
Hospital discharge: ICD-9 5641
Hospital discharge: ICD-8 56419
Cause of death: ICD-10 K58
Cause of death: ICD-9 5641
Cause of death: ICD-8 56419

8552

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

8397

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Check minimum number of events None

8397

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Include endpoints None

8397

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K11_IBS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K55-K63
Name in latin Syndroma intestini irritabilis

Summary Statistics

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Key figures

All Female Male
Number of individuals 8397 6139 2258
Unadjusted prevalence (%) 2.36 3.09 1.43
Mean age at first event (years) 48.87 48.17 50.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.27 [0.88, 1.82] 2.0e-1 494
15 years 0.01 0.96 [0.72, 1.29] 8.0e-1 235
5 years 0.00 1.60 [1.21, 2.12] 1.1e-3 109
1 year 0.00 3.11 [2.12, 4.55] 5.6e-9 38

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_IBS – Irritable bowel syndrome
GWS hits:

Survival analyses between endpoints

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Plot

before Irritable bowel syndrome
after Irritable bowel syndrome

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Drugs most likely to be purchased after Irritable bowel syndrome

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