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Speech and linguistic disorders

DOID EFO MESH PheWeb

KRA_PSY_SPEELING

autism: A disorder characterized by marked impairments in social interaction and communication accompanied by a pattern of repetitive, stereotyped behaviors and activities. Developmental delays in social interaction and language surface prior to age 3 years.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F80, F81
Hospital discharge: ICD-9 315[0-3]|3159
Hospital discharge: ICD-8 31610
Cause of death: ICD-10 F80, F81
Cause of death: ICD-9 315[0-3]|3159
Cause of death: ICD-8 31610

2503

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2447

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Check minimum number of events None

2447

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Include endpoints None

2447

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KRA_PSY_SPEELING

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 2447 1193 1254
Unadjusted prevalence (%) 0.69 0.60 0.80
Mean age at first event (years) 20.47 23.26 17.81

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.74 [1.87, 7.47] 1.8e-4 66
15 years 0.01 1.12 [0.51, 2.42] 7.8e-1 14
5 years 0.00 3.16 [1.54, 6.48] 1.8e-3 25
1 year 0.00 10.25 [4.81, 21.84] 1.6e-9 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: KRA_PSY_SPEELING – Speech and linguistic disorders
GWS hits:

Survival analyses between endpoints

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Plot

before Speech and linguistic disorders
after Speech and linguistic disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Speech and linguistic disorders

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