Drug phototoxic response

L12_DRUGPHOTOX

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 L56.0#
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 L56.0#
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

21

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

21

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Check minimum number of events None

21

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Include endpoints None

21

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L12_DRUGPHOTOX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L56
Name in latin Reactio phototoxica medicamento provocata

Summary Statistics

Key figures

All Female Male
Number of individuals 21 13 8
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 56.03 54.64 58.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_DRUGPHOTOX – Drug phototoxic response
GWS hits:

Survival analyses between endpoints

Plot

before Drug phototoxic response
after Drug phototoxic response

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Drugs most likely to be purchased after Drug phototoxic response