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Radiation-related disorders of the skin and subcutaneous tissue

DOID EFO MESH SNOMED PheWeb

L12_RADIATIONRELATEDSKIN

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 L55-L59
Cause of death: ICD-10 L55-L59

10361

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

10361

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Check minimum number of events None

10361

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Include endpoints

10858

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L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Radiation-related disorders of the skin and subcutaneous tissue based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 10858 5551 5307
Unadjusted prevalence (%) 3.05 2.80 3.37
Mean age at first event (years) 68.56 67.30 69.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.76 [1.39, 2.23] 2.2e-6 1278
15 years 0.01 0.99 [0.81, 1.20] 8.8e-1 576
5 years 0.00 2.02 [1.69, 2.41] 6.7e-15 491
1 year 0.00 2.22 [1.74, 2.82] 8.5e-11 106

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_RADIATIONRELATEDSKIN – Radiation-related disorders of the skin and subcutaneous tissue
GWS hits:

Survival analyses between endpoints

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Plot

before Radiation-related disorders of the skin and subcutaneous tissue
after Radiation-related disorders of the skin and subcutaneous tissue

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Drugs most likely to be purchased after Radiation-related disorders of the skin and subcutaneous tissue

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