Radiation-related disorders of the skin and subcutaneous tissue

L12_RADIATIONRELATEDSKIN

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 L55-L59
Cause of death: ICD-10 L55-L59

10361

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

10361

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Check minimum number of events None

10361

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L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Radiation-related disorders of the skin and subcutaneous tissue based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 10858 5551 5307
Unadjusted prevalence (%) 3.05 2.80 3.37
Mean age at first event (years) 68.56 67.30 69.87

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.76 [1.39, 2.23] 2.2e-6 1278
15 years 0.01 0.99 [0.81, 1.20] 8.8e-1 576
5 years 0.00 2.02 [1.69, 2.41] 6.7e-15 491
1 year 0.00 2.22 [1.74, 2.82] 8.5e-11 106

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_RADIATIONRELATEDSKIN – Radiation-related disorders of the skin and subcutaneous tissue
GWS hits:

Survival analyses between endpoints

Plot

before Radiation-related disorders of the skin and subcutaneous tissue
after Radiation-related disorders of the skin and subcutaneous tissue

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Drugs most likely to be purchased after Radiation-related disorders of the skin and subcutaneous tissue