Other and unspecified skin changes due to chronic exposure to nonionizing radiation

L12_NONIONRADISKINNAS

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 L57.8, L57.9
Hospital discharge: ICD-9 7093C
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 L57.8, L57.9
Cause of death: ICD-9 7093C
Cause of death: ICD-8 $!$

327

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

327

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Check minimum number of events None

327

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Include endpoints None

327

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L12_NONIONRADISKINNAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 327 167 160
Unadjusted prevalence (%) 0.09 0.08 0.10
Mean age at first event (years) 65.95 62.75 69.30

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.13 [0.56, 2.28] 7.3e-1 56
15 years 0.01 0.81 [0.45, 1.43] 4.6e-1 30
5 years 0.00 1.16 [0.65, 2.07] 6.2e-1 16
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: L12_NONIONRADISKINNAS – Other and unspecified skin changes due to chronic exposure to nonionizing radiation
GWS hits: 1

Survival analyses between endpoints

Plot

before Other and unspecified skin changes due to chronic exposure to nonionizing radiation
after Other and unspecified skin changes due to chronic exposure to nonionizing radiation

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Drugs most likely to be purchased after Other and unspecified skin changes due to chronic exposure to nonionizing radiation