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Systemic lupus erythematosus

DOID EFO MESH SNOMED PheWeb

M13_SLE

systemic lupus erythematosus: An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M32
Hospital discharge: ICD-9 7100
Hospital discharge: ICD-8 7431
Cause of death: ICD-10 M32
Cause of death: ICD-9 7100
Cause of death: ICD-8 7431

1092

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

951

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Check minimum number of events None

951

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Include endpoints None

951

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M13_SLE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M30-M36
Name in latin Lupus erythematosus disseminatus (LED)

Summary Statistics

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Key figures

All Female Male
Number of individuals 951 789 162
Unadjusted prevalence (%) 0.27 0.40 0.10
Mean age at first event (years) 45.74 44.67 50.96

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.40 [1.93, 5.99] 2.2e-5 87
15 years 0.02 2.34 [1.42, 3.85] 8.7e-4 34
5 years 0.01 4.62 [2.76, 7.73] 5.9e-9 21
1 year 0.00 14.57 [7.89, 26.91] 1.1e-17 13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SLE – Systemic lupus erythematosus
GWS hits:

Survival analyses between endpoints

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Plot

before Systemic lupus erythematosus
after Systemic lupus erythematosus

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Drugs most likely to be purchased after Systemic lupus erythematosus

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