Systemic connective tissue disorders

M13_SYSTCONNECT

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

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FinnGen phenotype data

356077 individuals

Apply sex-specific rule None

356077

Check conditions None

356077

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

M13_POLYARTERETAL

M13_NECROVASC

M13_SLE

M13_DERMATOPOLY

M13_SYSTSLCE

M13_OTHCONN

10700

M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

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Or the full data table

Similar endpoints

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List of similar endpoints to Systemic connective tissue disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	10700	7622	3078
Unadjusted prevalence (%)	3.01	3.84	1.96
Mean age at first event (years)	55.39	52.92	61.49

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	2.80 [2.31, 3.39]	6.9e-26	1259
15 years	0.01	1.39 [1.16, 1.67]	3.1e-4	494
5 years	0.00	3.00 [2.57, 3.49]	2.6e-45	398
1 year	0.00	7.84 [6.53, 9.41]	<1e-100	212

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SYSTCONNECT – Systemic connective tissue disorders
GWS hits: 6

Survival analyses between endpoints

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Plot

before Systemic connective tissue disorders
after Systemic connective tissue disorders

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Table

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Drugs most likely to be purchased after Systemic connective tissue disorders

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≡ Risteys

R8

R7

R6

R5

R4

R3