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Macular hole

DOID EFO MESH SNOMED PheWeb

MACULAR_HOLE

macular holes: Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 H35.37#
Hospital discharge: ICD-9 3625D
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H35.37#
Cause of death: ICD-9 3625D
Cause of death: ICD-8 $!$

1118

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1118

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Check minimum number of events None

1118

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Include endpoints None

1118

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MACULAR_HOLE

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35

Summary Statistics

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Key figures

All Female Male
Number of individuals 1118 663 455
Unadjusted prevalence (%) 0.31 0.33 0.29
Mean age at first event (years) 70.36 68.69 72.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.25 [2.65, 10.40] 2.0e-6 69
15 years 0.01 1.60 [0.75, 3.42] 2.3e-1 21
5 years 0.01 4.03 [2.24, 7.25] 3.2e-6 37
1 year 0.00 4.79 [2.26, 10.16] 4.3e-5 11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: MACULAR_HOLE – Macular hole
GWS hits: 2

Survival analyses between endpoints

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Plot

before Macular hole
after Macular hole

loading spinner Loading survival analyses plot