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Pre-eclampsia

DOID EFO MESH SNOMED PheWeb

O15_PREECLAMPS

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule

Sex only females

198506

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Check conditions None

198506

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Filter registries

Hospital Discharge: ICD-10 O14
Hospital discharge: ICD-9 642[4-5]
Hospital discharge: ICD-8 6370[349]
Cause of death: ICD-10 O14
Cause of death: ICD-9 642[4-5]
Cause of death: ICD-8 6370[349]

6103

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6103

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Check minimum number of events None

6103

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Include endpoints None

6103

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O15_PREECLAMPS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O10-O16
Name in latin Hypertensio gestationalis cum proteinuria significanti

Summary Statistics

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Key figures

All Female Male
Number of individuals 6103 6103 -
Unadjusted prevalence (%) 1.72 3.08 -
Mean age at first event (years) 29.10 29.10 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.50 [0.36, 0.69] 2.1e-5 103
15 years 0.00 0.30 [0.19, 0.47] 1.8e-7 27
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_PREECLAMPS – Pre-eclampsia
GWS hits: 1

Survival analyses between endpoints

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Plot

before Pre-eclampsia
after Pre-eclampsia

loading spinner Loading survival analyses plot