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Pregnancy hypertension

DOID EFO MESH SNOMED PheWeb

O15_HYPTENSPREG

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule

Sex only females

198506

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Check conditions None

198506

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Filter registries

Hospital Discharge: ICD-10 O10, O11, O13, O14, O15, O16
Hospital discharge: ICD-9 642
Hospital discharge: ICD-8 63701|63703|63704|63709|63710|63799|66120
Cause of death: ICD-10 O10, O11, O13, O14, O15, O16
Cause of death: ICD-9 642
Cause of death: ICD-8 63701|63703|63704|63709|63710|63799

13446

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

13410

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Check minimum number of events None

13410

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Include endpoints None

13410

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O15_HYPTENSPREG

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Pregnancy hypertension based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 13410 13410 -
Unadjusted prevalence (%) 3.77 6.76 -
Mean age at first event (years) 29.66 29.66 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.77 [0.61, 0.97] 2.9e-2 256
15 years 0.00 0.53 [0.39, 0.71] 1.7e-5 78
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: O15_HYPTENSPREG – Pregnancy hypertension
GWS hits: 16

Survival analyses between endpoints

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Plot

before Pregnancy hypertension
after Pregnancy hypertension

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Drugs most likely to be purchased after Pregnancy hypertension

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