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Cleft lip, lip and palate or palate

DOID EFO MESH PheWeb

Q17_CLEFT_LIP_CLEFT_PALATE

cleft lip: ['Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not Q17_CLEFT_PALATE_EXCLUDE

355562

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Filter registries

Hospital Discharge: ICD-10 Q35-Q37
Hospital discharge: ICD-9 749
Hospital discharge: ICD-8 74900|74910|74911|74912|74913|74920|74924|74929
Cause of death: ICD-10 Q35-Q37
Cause of death: ICD-9 749
Cause of death: ICD-8 74900|74910|74911|74912|74913|74920|74924|74929

423

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

416

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Check minimum number of events None

416

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Include endpoints None

416

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Q17_CLEFT_LIP_CLEFT_PALATE

Extra metadata

First used in FinnGen datafreeze DF7

Summary Statistics

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Key figures

All Female Male
Number of individuals 416 256 160
Unadjusted prevalence (%) 0.12 0.13 0.10
Mean age at first event (years) 12.44 11.79 13.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: Q17_CLEFT_LIP_CLEFT_PALATE – Cleft lip, lip and palate or palate
GWS hits: 4

Survival analyses between endpoints

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Plot

before Cleft lip, lip and palate or palate
after Cleft lip, lip and palate or palate

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cleft lip, lip and palate or palate

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