Congenital malformations, deformations and chromosomal abnormalities

Q17_CONGEN_MALFO_DEFORMAT_CHROMOSOMAL_ABNORMALITI

No definition available.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 Q00-Q99
Hospital discharge: ICD-9 7[4-5]
Hospital discharge: ICD-8 7[4-5]
Cause of death: ICD-10 Q00-Q99
Cause of death: ICD-9 7[4-5]
Cause of death: ICD-8 7[4-5]

22125

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

22125

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Check minimum number of events None

22125

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Include endpoints None

22125

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Q17_CONGEN_MALFO_DEFORMAT_CHROMOSOMAL_ABNORMALITI

Extra metadata

Level in the ICD hierarchy 1
Special XVII_MALFORMAT_ABNORMAL
First used in FinnGen datafreeze DF4

Similar endpoints

List of similar endpoints to Congenital malformations, deformations and chromosomal abnormalities based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 22125 13432 8693
Unadjusted prevalence (%) 6.22 6.77 5.52
Mean age at first event (years) 29.93 30.18 29.55

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.75 [1.46, 2.09] 8.9e-10 1172
15 years 0.01 1.24 [1.05, 1.47] 1.3e-2 500
5 years 0.00 1.86 [1.53, 2.25] 3.3e-10 215
1 year 0.00 3.96 [3.05, 5.15] 8.9e-25 85

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: Q17_CONGEN_MALFO_DEFORMAT_CHROMOSOMAL_ABNORMALITI – Congenital malformations, deformations and chromosomal abnormalities
GWS hits:

Survival analyses between endpoints

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before Congenital malformations, deformations and chromosomal abnormalities
after Congenital malformations, deformations and chromosomal abnormalities

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Drugs most likely to be purchased after Congenital malformations, deformations and chromosomal abnormalities