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Congenital malformations of heart and great arteries

DOID MESH PheWeb

CONGEN_HEART_ARTER

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 Q20, Q21, Q22, Q23, Q24, Q25
Hospital discharge: ICD-9 745|746|747[0-3]
Hospital discharge: ICD-8 746|747[0-3]
Cause of death: ICD-10 Q20, Q21, Q22, Q23, Q24, Q25
Cause of death: ICD-9 745|746|747[0-3]
Cause of death: ICD-8 746|747[0-3]

4370

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3613

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Check minimum number of events None

3613

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Include endpoints None

3613

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CONGEN_HEART_ARTER

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Congenital malformations of heart and great arteries based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 3613 1856 1757
Unadjusted prevalence (%) 1.02 0.94 1.12
Mean age at first event (years) 30.98 28.14 33.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.31 [2.27, 4.82] 4.8e-10 193
15 years 0.01 1.98 [1.40, 2.80] 1.1e-4 82
5 years 0.00 3.03 [2.02, 4.56] 8.9e-8 39
1 year 0.00 9.73 [5.99, 15.82] 4.3e-20 23

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CONGEN_HEART_ARTER – Congenital malformations of heart and great arteries
GWS hits: 3

Survival analyses between endpoints

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Plot

before Congenital malformations of heart and great arteries
after Congenital malformations of heart and great arteries

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Drugs most likely to be purchased after Congenital malformations of heart and great arteries

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