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Vocal cord dysfunction

DOID EFO MESH SNOMED PheWeb

VOCALCORDDYS

human african trypanosomiasis: A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 J38.3
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 J38.3
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

963

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

963

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Check minimum number of events None

963

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Include endpoints None

963

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VOCALCORDDYS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J38
Name in latin Alii morbi plicarum vocalium

Summary Statistics

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Key figures

All Female Male
Number of individuals 963 468 495
Unadjusted prevalence (%) 0.27 0.24 0.31
Mean age at first event (years) 55.46 52.16 58.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.31 [0.65, 2.65] 4.5e-1 86
15 years 0.01 0.81 [0.39, 1.69] 5.7e-1 41
5 years 0.00 2.29 [1.22, 4.28] 9.5e-3 29
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: VOCALCORDDYS – Vocal cord dysfunction
GWS hits:

Survival analyses between endpoints

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Plot

before Vocal cord dysfunction
after Vocal cord dysfunction

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Vocal cord dysfunction

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