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Malignant neoplasm of breast, HER-positive

PheWeb

C3_BREAST_HERPLUS

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule

Sex only females

198506

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Check conditions

RX_HERPLUS

8420

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Filter registries

Cause of death: ICD-10 C50
Cause of death: ICD-9 174
Cause of death: ICD-8 174
Cancer registry: Topography ICD-O-3 C50

7960

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

7960

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Check minimum number of events None

7960

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Include endpoints None

7960

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C3_BREAST_HERPLUS

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF5

Summary Statistics

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Key figures

All Female Male
Number of individuals 7960 7960 -
Unadjusted prevalence (%) 2.24 4.01 -
Mean age at first event (years) 58.92 58.92 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.68 [1.16, 2.44] 5.8e-3 702
15 years 0.01 1.18 [0.85, 1.64] 3.2e-1 367
5 years 0.00 2.26 [1.74, 2.93] 8.6e-10 217
1 year 0.00 0.64 [0.34, 1.21] 1.7e-1 11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_BREAST_HERPLUS – Malignant neoplasm of breast, HER-positive
GWS hits:

Survival analyses between endpoints

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Plot

before Malignant neoplasm of breast, HER-positive
after Malignant neoplasm of breast, HER-positive

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Drugs most likely to be purchased after Malignant neoplasm of breast, HER-positive

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