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Early onset COPD

DOID EFO MESH SNOMED PheWeb

COPD_EARLY

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 J44
Hospital discharge: ICD-9 4912
Hospital discharge: ICD-8 49104
Cause of death: ICD-10 J44
Cause of death: ICD-9 4912
Cause of death: ICD-8 49104

16161

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Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE<65
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6579

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Check minimum number of events None

6579

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Include endpoints None

6579

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COPD_EARLY

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Alii morbi obstructivi chronici pulmonum

Summary Statistics

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Key figures

All Female Male
Number of individuals 6579 2429 4150
Unadjusted prevalence (%) 1.85 1.22 2.64
Mean age at first event (years) 54.60 52.74 55.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.45 [2.60, 4.59] 1.1e-17 1485
15 years 0.02 2.63 [2.15, 3.22] 3.9e-21 741
5 years 0.01 4.37 [3.69, 5.18] 3.1e-65 354
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: COPD_EARLY – Early onset COPD
GWS hits: 5

Survival analyses between endpoints

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Plot

before Early onset COPD
after Early onset COPD

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Early onset COPD

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