COPD, early/later onset

COPD_EARLYANDLATER

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

16161

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COPD_EARLYANDLATER

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 16161 4089 12072
Unadjusted prevalence (%) 4.54 2.06 7.67
Mean age at first event (years) 66.17 60.91 67.95

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: COPD_EARLYANDLATER – COPD, early/later onset
GWS hits:

Survival analyses between endpoints

Plot

before COPD, early/later onset
after COPD, early/later onset

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Drugs most likely to be purchased after COPD, early/later onset