Eosinophilia

D3_EOSINOPHILIA

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D72.1
Hospital discharge: ICD-9 2883
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 D72.1
Cause of death: ICD-9 2883
Cause of death: ICD-8 $!$

375

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

375

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Check minimum number of events None

375

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Include endpoints None

375

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D3_EOSINOPHILIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D72
Name in latin Eosinophilia

Similar endpoints

Summary Statistics

Key figures

All Female Male
Number of individuals 375 196 179
Unadjusted prevalence (%) 0.11 0.10 0.11
Mean age at first event (years) 53.96 50.36 57.90

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.92 [1.01, 3.65] 4.5e-2 38
15 years 0.01 0.82 [0.39, 1.69] 5.8e-1 14
5 years 0.00 2.41 [1.10, 5.29] 2.8e-2 15
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_EOSINOPHILIA – Eosinophilia
GWS hits:

Survival analyses between endpoints

Plot

before Eosinophilia
after Eosinophilia

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