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Eosinophilic disease (BM)

DOID EFO MESH SNOMED PheWeb

ESOSINOPHIL_DISEASE

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D72.1
Hospital discharge: ICD-9 2883
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 D72.1
Cause of death: ICD-9 2883
Cause of death: ICD-8 $!$

375

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

375

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Check minimum number of events None

375

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Include endpoints None

375

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ESOSINOPHIL_DISEASE

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 D72
Name in latin Eosinophilia

Summary Statistics

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Key figures

All Female Male
Number of individuals 375 196 179
Unadjusted prevalence (%) 0.11 0.10 0.11
Mean age at first event (years) 53.96 50.36 57.90

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ESOSINOPHIL_DISEASE – Eosinophilic disease (BM)
GWS hits: 1

Survival analyses between endpoints

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Plot

before Eosinophilic disease (BM)
after Eosinophilic disease (BM)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Eosinophilic disease (BM)

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