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Other disorders of white blood cells

DOID EFO MESH SNOMED PheWeb

D3_OTHERWHITECELL

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D72
Cause of death: ICD-10 D72

1292

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

1292

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Check minimum number of events None

1292

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Include endpoints

1374

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D3_OTHERWHITECELL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D70-D77
Name in latin Aliae morbositates leucocytorum

Similar endpoints

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List of similar endpoints to Other disorders of white blood cells based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

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Key figures

All Female Male
Number of individuals 1374 716 658
Unadjusted prevalence (%) 0.39 0.36 0.42
Mean age at first event (years) 54.46 50.69 58.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.79 [1.66, 4.68] 1.1e-4 202
15 years 0.01 1.48 [0.98, 2.23] 6.0e-2 74
5 years 0.00 3.66 [2.52, 5.31] 9.4e-12 70
1 year 0.00 8.94 [5.69, 14.05] 2.1e-21 34

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other disorders of white blood cells
after Other disorders of white blood cells

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Drugs most likely to be purchased after Other disorders of white blood cells

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