Other disorders of white blood cells

D3_OTHERWHITECELL

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 D72
Cause of death: ICD-10 D72

1292

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

1292

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Check minimum number of events None

1292

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D3_OTHERWHITECELL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D70-D77
Name in latin Aliae morbositates leucocytorum

Similar endpoints

List of similar endpoints to Other disorders of white blood cells based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 1374 716 658
Unadjusted prevalence (%) 0.39 0.36 0.42
Mean age at first event (years) 54.46 50.69 58.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.79 [1.66, 4.68] 1.1e-4 202
15 years 0.01 1.48 [0.98, 2.23] 6.0e-2 74
5 years 0.00 3.66 [2.52, 5.31] 9.4e-12 70
1 year 0.00 8.94 [5.69, 14.05] 2.1e-21 34

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits: 1

Survival analyses between endpoints

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before Other disorders of white blood cells
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Drugs most likely to be purchased after Other disorders of white blood cells