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Diabetes, several complications

DOID EFO MESH SNOMED PheWeb

DM_SEVERAL_COMPLICATIONS

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E10.7, E10.8, E11.7, E11.8, E12.7, E12.8, E13.7, E13.8, E14.7, E14.8
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Hospital discharge: excluded ICD-10 E12.7, E12.8
Cause of death: ICD-10 E10.7, E10.8, E11.7, E11.8, E12.7, E12.8, E13.7, E13.8, E14.7, E14.8
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

14080

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

14080

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Check minimum number of events None

14080

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Include endpoints None

14080

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DM_SEVERAL_COMPLICATIONS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 14080 5393 8687
Unadjusted prevalence (%) 3.96 2.72 5.52
Mean age at first event (years) 62.64 60.49 63.97

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 7.62 [6.60, 8.78] <1e-100 3730
15 years 0.02 2.84 [2.45, 3.30] 1.8e-42 1133
5 years 0.01 6.28 [5.56, 7.09] <1e-100 1242
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_SEVERAL_COMPLICATIONS – Diabetes, several complications
GWS hits: 12

Survival analyses between endpoints

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Plot

before Diabetes, several complications
after Diabetes, several complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetes, several complications

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