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Dry age-related macular degeneration (includes geographic atrophy)

DOID EFO MESH SNOMED PheWeb

DRY_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not DRY_AMD_EARLY

355971

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Filter registries

Hospital Discharge: ICD-10 H35.30
Hospital discharge: ICD-9 3625A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H35.30
Cause of death: ICD-9 3625A
Cause of death: ICD-8 $!$

5272

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Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE>=50
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5272

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Check minimum number of events None

5272

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Include endpoints None

5272

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DRY_AMD

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Degeneratio maculae senilis atrophica

Summary Statistics

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Key figures

All Female Male
Number of individuals 5272 2751 2521
Unadjusted prevalence (%) 1.48 1.39 1.60
Mean age at first event (years) 75.46 75.43 75.51

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.54 [1.87, 3.46] 3.1e-9 1153
15 years 0.01 1.22 [0.95, 1.57] 1.1e-1 491
5 years 0.00 2.41 [2.03, 2.85] 2.9e-24 476
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DRY_AMD – Dry age-related macular degeneration (includes geographic atrophy)
GWS hits: 19

Survival analyses between endpoints

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Plot

before Dry age-related macular degeneration (includes geographic atrophy)
after Dry age-related macular degeneration (includes geographic atrophy)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Dry age-related macular degeneration (includes geographic atrophy)

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