Age-related macular degeneration (whether dry or wet)

H7_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

7832

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H7_AMD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 7832 4016 3816
Unadjusted prevalence (%) 2.20 2.02 2.42
Mean age at first event (years) 75.05 75.11 75.00

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.29 [1.89, 2.77] 4.4e-17 1635
15 years 0.01 1.11 [0.91, 1.35] 3.0e-1 720
5 years 0.00 2.18 [1.87, 2.54] 2.9e-23 653
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_AMD – Age-related macular degeneration (whether dry or wet)
GWS hits: 22

Survival analyses between endpoints

Plot

before Age-related macular degeneration (whether dry or wet)
after Age-related macular degeneration (whether dry or wet)

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Drugs most likely to be purchased after Age-related macular degeneration (whether dry or wet)