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Disorders of calcium metabolism

DOID EFO MESH SNOMED PheWeb

E4_CA_MET

calcium metabolic disease: Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E83.50, E83.50+F02.89, E83.50+N16.3, E83.51, E83.58, E83.59
Hospital discharge: ICD-9 2754
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E83.50, E83.50+F02.89, E83.50+N16.3, E83.51, E83.58, E83.59
Cause of death: ICD-9 2754
Cause of death: ICD-8 $!$

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

1466

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E4_CA_MET

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1466 890 576
Unadjusted prevalence (%) 0.41 0.45 0.37
Mean age at first event (years) 60.42 59.05 62.55

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 8.07 [4.55, 14.30] 9.0e-13 282
15 years 0.01 1.68 [0.99, 2.88] 5.7e-2 44
5 years 0.01 6.91 [4.46, 10.71] 4.9e-18 80
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_CA_MET – Disorders of calcium metabolism
GWS hits:

Survival analyses between endpoints

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Plot

before Disorders of calcium metabolism
after Disorders of calcium metabolism

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Drugs most likely to be purchased after Disorders of calcium metabolism

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