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Cushing syndrome

DOID EFO MESH SNOMED PheWeb

E4_CUSHING

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E24
Hospital discharge: ICD-9 2550|2593
Hospital discharge: ICD-8 2580
Cause of death: ICD-10 E24
Cause of death: ICD-9 2550|2593
Cause of death: ICD-8 2580

321

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

274

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Check minimum number of events None

274

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Include endpoints None

274

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E4_CUSHING

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 E20-E35
Name in latin Syndroma Cushing

Summary Statistics

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Key figures

All Female Male
Number of individuals 274 196 78
Unadjusted prevalence (%) 0.08 0.10 0.05
Mean age at first event (years) 46.23 44.35 50.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.70 [1.06, 12.90] 4.0e-2 36
15 years 0.01 1.92 [0.70, 5.27] 2.1e-1 11
5 years 0.01 7.66 [3.61, 16.24] 1.1e-7 14
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_CUSHING – Cushing syndrome
GWS hits: 1

Survival analyses between endpoints

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Plot

before Cushing syndrome
after Cushing syndrome

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cushing syndrome

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