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Type 1 diabetes with renal complications

MESH PheWeb

E4_DM1REN

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E10.2+, E10.2+N08.39
Hospital discharge: ICD-9 2503B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E10.2+, E10.2+N08.39
Cause of death: ICD-9 2503B
Cause of death: ICD-8 $!$

1478

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1478

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Check minimum number of events None

1478

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Include endpoints None

1478

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E4_DM1REN

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1478 635 843
Unadjusted prevalence (%) 0.42 0.32 0.54
Mean age at first event (years) 42.60 38.64 45.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.24 16.29 [11.65, 22.78] 8.5e-60 303
15 years 0.05 7.54 [5.20, 10.95] 2.0e-26 122
5 years 0.02 16.32 [12.20, 21.82] 3.8e-79 101
1 year 0.00 21.87 [14.37, 33.28] 5.1e-47 30

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1REN – Type 1 diabetes with renal complications
GWS hits: 5

Survival analyses between endpoints

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Plot

before Type 1 diabetes with renal complications
after Type 1 diabetes with renal complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes with renal complications

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