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Type 1 diabetes

DOID EFO MESH SNOMED PheWeb

E4_DM1

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E10
Cause of death: ICD-10 E10

9076

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

9076

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Check minimum number of events None

9076

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Include endpoints

9591

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E4_DM1

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) juvenilis

Similar endpoints

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List of similar endpoints to Type 1 diabetes based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 9591 4450 5141
Unadjusted prevalence (%) 2.70 2.24 3.27
Mean age at first event (years) 34.10 31.29 36.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.77 [3.97, 5.74] 6.4e-62 1382
15 years 0.02 3.07 [2.61, 3.61] 4.5e-42 615
5 years 0.01 4.61 [3.93, 5.42] 5.6e-77 319
1 year 0.00 8.87 [7.15, 11.01] 2.3e-87 129

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1 – Type 1 diabetes
GWS hits:

Survival analyses between endpoints

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Plot

before Type 1 diabetes
after Type 1 diabetes

loading spinner Loading survival analyses plot