Other and/or unspecified nontoxic goitre

E4_GOITRENAS

goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E04.8, E04.9
Hospital discharge: ICD-9 2419
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E04.8, E04.9
Cause of death: ICD-9 2419
Cause of death: ICD-8 $!$

2996

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2176

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Check minimum number of events None

2176

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Include endpoints None

2176

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E4_GOITRENAS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 2176 1841 335
Unadjusted prevalence (%) 0.61 0.93 0.21
Mean age at first event (years) 54.48 53.38 60.50

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.54 [1.04, 2.29] 3.1e-2 161
15 years 0.01 0.97 [0.67, 1.38] 8.5e-1 61
5 years 0.00 2.30 [1.60, 3.31] 6.8e-6 41
1 year 0.00 5.16 [3.06, 8.69] 7.1e-10 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre
GWS hits: 14

Survival analyses between endpoints

Plot

before Other and/or unspecified nontoxic goitre
after Other and/or unspecified nontoxic goitre

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and/or unspecified nontoxic goitre