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Other and/or unspecified nontoxic goitre

DOID EFO MESH SNOMED PheWeb

E4_GOITRENAS

goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E04.8, E04.9
Hospital discharge: ICD-9 2419
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E04.8, E04.9
Cause of death: ICD-9 2419
Cause of death: ICD-8 $!$

2996

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2176

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Check minimum number of events None

2176

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Include endpoints None

2176

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E4_GOITRENAS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 2176 1841 335
Unadjusted prevalence (%) 0.61 0.93 0.21
Mean age at first event (years) 54.48 53.38 60.50

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.54 [1.04, 2.29] 3.1e-2 161
15 years 0.01 0.97 [0.67, 1.38] 8.5e-1 61
5 years 0.00 2.30 [1.60, 3.31] 6.8e-6 41
1 year 0.00 5.16 [3.06, 8.69] 7.1e-10 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre
GWS hits: 14

Survival analyses between endpoints

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Plot

before Other and/or unspecified nontoxic goitre
after Other and/or unspecified nontoxic goitre

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and/or unspecified nontoxic goitre

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