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Nontoxic single thyroid nodule

DOID EFO MESH SNOMED PheWeb

E4_GOITRENOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E04.1
Hospital discharge: ICD-9 2410|2462
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E04.1
Cause of death: ICD-9 2410|2462
Cause of death: ICD-8 $!$

1979

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1913

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Check minimum number of events None

1913

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Include endpoints None

1913

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E4_GOITRENOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E04
Name in latin Struma atoxica uninodularis

Summary Statistics

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Key figures

All Female Male
Number of individuals 1913 1544 369
Unadjusted prevalence (%) 0.54 0.78 0.23
Mean age at first event (years) 50.87 49.26 57.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.80 [0.43, 1.50] 4.9e-1 96
15 years 0.00 0.56 [0.32, 0.97] 3.8e-2 39
5 years 0.00 1.22 [0.67, 2.22] 5.2e-1 22
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule
GWS hits: 2

Survival analyses between endpoints

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Plot

before Nontoxic single thyroid nodule
after Nontoxic single thyroid nodule

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Drugs most likely to be purchased after Nontoxic single thyroid nodule

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