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Mixed hyperlipidaemia

DOID EFO MESH PheWeb

E4_HYPERLIPMIX

obsolete_familial combined hyperlipidemia: ['A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E78.2
Hospital discharge: ICD-9 2722
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E78.2
Cause of death: ICD-9 2722
Cause of death: ICD-8 $!$

980

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

980

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Check minimum number of events None

980

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Include endpoints None

980

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E4_HYPERLIPMIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E78

Summary Statistics

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Key figures

All Female Male
Number of individuals 980 341 639
Unadjusted prevalence (%) 0.28 0.17 0.41
Mean age at first event (years) 55.59 56.25 55.24

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.12 [2.06, 4.72] 7.5e-8 187
15 years 0.01 2.11 [1.45, 3.06] 9.4e-5 93
5 years 0.00 2.89 [1.87, 4.45] 1.5e-6 41
1 year 0.00 6.05 [3.37, 10.85] 1.7e-9 16

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERLIPMIX – Mixed hyperlipidaemia
GWS hits: 5

Survival analyses between endpoints

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Plot

before Mixed hyperlipidaemia
after Mixed hyperlipidaemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed hyperlipidaemia

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