hyperparathyroidism: Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E21.09, E21.1, E21.2, E21.3
Hospital discharge: ICD-9 2520
Hospital discharge: ICD-8 2520
Cause of death: ICD-10 E21.09, E21.1, E21.2, E21.3
Cause of death: ICD-9 2520
Cause of death: ICD-8 2520
Medicine purchases: ATC H05B


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events

Min. number of events 3


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 5134 3744 1390
Unadjusted prevalence (%) 1.44 1.89 0.88
Mean age at first event (years) 63.13 62.86 63.87


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.81 [2.32, 3.41] 2.8e-26 1143
15 years 0.01 1.70 [1.45, 1.99] 3.0e-11 549
5 years 0.00 2.71 [2.34, 3.14] 6.1e-40 341
1 year 0.00 4.20 [3.36, 5.26] 2.3e-36 105

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_HYPERPARA – Hyperparathyroidism
GWS hits: 6

Survival analyses between endpoints


before Hyperparathyroidism
after Hyperparathyroidism

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Drugs most likely to be purchased after Hyperparathyroidism