Disorders of parathyroid gland


hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E20, E21
Cause of death: ICD-10 E20, E21


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Include endpoints


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 5831 4285 1546
Unadjusted prevalence (%) 1.64 2.16 0.98
Mean age at first event (years) 62.14 61.81 63.07


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.37 [1.75, 3.20] 2.1e-8 1215
15 years 0.01 1.51 [1.22, 1.88] 1.9e-4 573
5 years 0.00 2.63 [2.22, 3.12] 6.7e-29 363
1 year 0.00 4.46 [3.55, 5.59] 4.6e-38 119

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_PARATHYRO – Disorders of parathyroid gland
GWS hits: 6

Survival analyses between endpoints


before Disorders of parathyroid gland
after Disorders of parathyroid gland

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Drugs most likely to be purchased after Disorders of parathyroid gland