Secondary lactase deficiency

E4_LACTOSEC

lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E73.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E73.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

33

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

33

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Check minimum number of events None

33

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Include endpoints None

33

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E4_LACTOSEC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E73
Name in latin Deficientia lactasae secundaria

Summary Statistics

Key figures

All Female Male
Number of individuals 33 20 13
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 42.12 37.73 48.86

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_LACTOSEC – Secondary lactase deficiency
GWS hits:

Survival analyses between endpoints

Plot

before Secondary lactase deficiency
after Secondary lactase deficiency

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Drugs most likely to be purchased after Secondary lactase deficiency