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Thyroid crisis or storm

DOID EFO MESH SNOMED PheWeb

E4_THYCRISIS

Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E05.5
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E05.5
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

60

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

60

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Check minimum number of events None

60

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Include endpoints None

60

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E4_THYCRISIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Crisis thyreotoxica

Summary Statistics

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Key figures

All Female Male
Number of individuals 60 45 15
Unadjusted prevalence (%) 0.02 0.02 0.01
Mean age at first event (years) 49.06 48.32 51.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYCRISIS – Thyroid crisis or storm
GWS hits:

Survival analyses between endpoints

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Plot

before Thyroid crisis or storm
after Thyroid crisis or storm

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Thyroid crisis or storm

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