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Thyrotoxicosis with diffuse goitre

DOID EFO MESH SNOMED PheWeb

E4_THYTOXGOITDIF

Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E05.0
Hospital discharge: ICD-9 2420
Hospital discharge: ICD-8 2420
Cause of death: ICD-10 E05.0
Cause of death: ICD-9 2420
Cause of death: ICD-8 2420

4102

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4102

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Check minimum number of events None

4102

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Include endpoints None

4102

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E4_THYTOXGOITDIF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma diffusa

Summary Statistics

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Key figures

All Female Male
Number of individuals 4102 3418 684
Unadjusted prevalence (%) 1.15 1.72 0.43
Mean age at first event (years) 48.63 47.80 52.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.33 [0.86, 2.08] 2.0e-1 172
15 years 0.01 0.98 [0.66, 1.44] 9.0e-1 78
5 years 0.00 1.64 [1.08, 2.48] 1.9e-2 39
1 year 0.00 4.67 [2.80, 7.79] 3.5e-9 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXGOITDIF – Thyrotoxicosis with diffuse goitre
GWS hits: 16

Survival analyses between endpoints

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Plot

before Thyrotoxicosis with diffuse goitre
after Thyrotoxicosis with diffuse goitre

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Drugs most likely to be purchased after Thyrotoxicosis with diffuse goitre

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