Bipolar affective disorders


bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 F31
Hospital discharge: ICD-9 296[2-7]
Hospital discharge: ICD-8 296
Hospital discharge: excluded ICD-8 2960|29699
Cause of death: ICD-10 F31
Cause of death: ICD-9 296[2-7]
Cause of death: ICD-8 296
Cause of death: excluded ICD-8 2960|29699


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F30-F39
Name in latin Perturbatio affectiva bipolaris

Summary Statistics

Key figures

All Female Male
Number of individuals 6562 4127 2435
Unadjusted prevalence (%) 1.84 2.08 1.55
Mean age at first event (years) 39.45 37.97 41.95


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.62 [1.96, 3.49] 6.0e-11 358
15 years 0.02 2.19 [1.70, 2.82] 1.0e-9 183
5 years 0.00 2.88 [2.15, 3.87] 1.9e-12 66
1 year 0.00 6.20 [4.02, 9.57] 1.5e-16 25

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: F5_BIPO – Bipolar affective disorders
GWS hits: 1

Survival analyses between endpoints


before Bipolar affective disorders
after Bipolar affective disorders

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Drugs most likely to be purchased after Bipolar affective disorders