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Dementia

DOID EFO MESH PheWeb

F5_DEMENTIA

obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F00-F09
Hospital discharge: ICD-9 290|3310|4378A
Hospital discharge: ICD-8 290
Cause of death: ICD-10 F00-F09
Cause of death: ICD-9 290|3310|4378A
Cause of death: ICD-8 290
KELA reimbursements: KELA codes 307
Medicine purchases: ATC N06D

14622

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

13969

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Check minimum number of events

Min. number of events 3

13969

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Include endpoints

13999

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F5_DEMENTIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 13999 5758 8241
Unadjusted prevalence (%) 3.93 2.90 5.24
Mean age at first event (years) 77.27 77.46 77.14

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.15 7.75 [6.75, 8.91] <1e-100 6846
15 years 0.02 2.63 [2.28, 3.03] 3.5e-40 1975
5 years 0.01 6.32 [5.73, 6.97] <1e-100 3296
1 year 0.00 11.05 [9.92, 12.31] <1e-100 1545

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_DEMENTIA – Dementia
GWS hits: 11

Survival analyses between endpoints

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Plot

before Dementia
after Dementia

loading spinner Loading survival analyses plot