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Dementia in Alzheimer disease

DOID EFO MESH SNOMED PheWeb

F5_ALZHDEMENT

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F00*
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 29010
Cause of death: ICD-10 F00*
Cause of death: ICD-9 $!$
Cause of death: ICD-8 29010

4561

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4561

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Check minimum number of events None

4561

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Include endpoints None

4561

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F5_ALZHDEMENT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 4561 1937 2624
Unadjusted prevalence (%) 1.28 0.98 1.67
Mean age at first event (years) 79.79 80.09 79.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.16 9.45 [8.19, 10.90] <1e-100 2535
15 years 0.02 2.25 [1.93, 2.62] 1.5e-25 563
5 years 0.01 6.87 [5.98, 7.89] <1e-100 1295
1 year 0.00 12.71 [10.83, 14.92] <1e-100 675

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_ALZHDEMENT – Dementia in Alzheimer disease
GWS hits: 4

Survival analyses between endpoints

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Plot

before Dementia in Alzheimer disease
after Dementia in Alzheimer disease

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Drugs most likely to be purchased after Dementia in Alzheimer disease

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